Selected Publications

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Rasha Msallam,* Jozef Balla,* Abhay P. S. Rathore, Hassen Kared, Benoit Malleret, Wilfried A. A. Saron, Zhaoyuan Liu, Jing Wen Hang, Charles Antoine Dutertre, Anis Larbi, Jerry K. Y. Chan, Ashley L. St. John, Florent Ginhoux, (2020). Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE. Science. doi: 10.1126/science.aba0864 (* co-first,  co-corresponding)




Rathore, A.P.S., Farouk, F.S., St John, A.L. (2020) Risk factors and biomarkers of severe dengue. Current Opinion in Virology. doi: 10.1016/j.coviro.2020.06.008


Rathore, A.P.S., Senanayake, M., Athapathu, A.S., Gunasena, S., Karunaratna, I., Leong, W.Y., Lim, T., Mantri, C.K., Wilder-Smith, A., St John, A.L. (2020) Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients. Scientific Reports. doi: 10.1038/s41598-020-68844-z

Rathore, A.P.S., St John, A.L. (2020) Protective and pathogenic roles for mast cells during viral infections. Current Opinion in Immunology. doi: 10.1016/j.coi.2020.05.003


Immanuel Kwok, Etienne Becht, Yu Xia, Melissa Ng, Ye Chean Teh, Leonard Tan, Maximilien Evrard, Jackson LY Li, Hoa TN Tran, Yingrou Tan, Dehua Liu, Archita Mishra, Ka Hang Liong, Keith Leong, Yuning Zhang, Andre Olsson, Chinmay Kumar Mantri, Pavithra Shyamsunder, Zhaoyuan Liu, Cecile Piot, Charles-Antoine Dutertre, Hui Cheng, Sudipto Bari, Nicholas Ang, Subhra K Biswas, H Philip Koeffler, Hong Liang Tey, Anis Larbi, I-Hsin Su, Bernett Lee, Ashley St John, Jerry KY Chan, William YK Hwang, Jinmiao Chen, Nathan Salomonis, Shu Zhen Chong, H Leighton Grimes, Bing Liu, Andrés Hidalgo, Evan W Newell, Tao Cheng, Florent Ginhoux, Lai Guan Ng. (2020) Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor. Immunity. doi10.1016/j.immuni.2020.06.005​



St John, A.L., Rathore, A.P.S. (2020) Early Insights into Immune Responses during COVID-19. Journal of Immunology. doi: 10.4049/jimmunol.2000526


Hsieh, J.T., St John, A.L. (2020) Japanese encephalitis virus and its mechanisms of neuroinvasion.  PLoS Pathogens. doi: 10.1371/journal.ppat.1008260

Rathore, A.P.S., St. John, A.L. (2020) Cross-Reactive Immunity Among Flaviviruses. Frontiers in Immunology. doi: 10.3389/fimmu.2020.00334


Rathore, A.P.S., Mantri, C.K., Aman, S.A.B., Syenina, A., Ooi, J., Jagaraj, C.J., Goh, C.C., Tissera, H., Wilder-Smith, A., Ng, L.G., Gubler, D.J, St. John, A.L. (2019) Dengue virus-elicited tryptase induces endothelial permeability and shock. Journal of Clinical Investigation. doi:10.1172/JCI128426


Masri, M.F.B., Rathore, A.P.S., St. John, A.L. (2019) Therapeutics for Dengue. Current Treatment Options in Infectious Diseases.  doi:10.1007/s40506-019-00193-6

Rathore, A.P.S., Saron, W.A.A., Lim, T., Jahan, N. and St. John, A.L. (2019) Maternal immunity and antibodies to dengue promote infection and Zika virus-induced microcephaly in fetuses. Science Advances. doi:10.1126/sciadv.aav3208


Masri, M.F.B., Mantri, C.K.M., Rathore, A.P.S., St. John, A.L. (2019) Peripheral serotonin causes dengue-induced thrombocytopenia through 5HT2 receptors. Blood. doi: 10.1182/blood-2018-08-869156



Hsieh, J., Rathore, A.P.S., Soundarajan, G., St. John, A.L. (2019). Japanese encephalitis virus neuropenetrance is driven by mast cell chymase. Nature Communications. 10, Article number: 706 doi: 10.1038/s41467-019-08641-z



St. John, A.L., and Rathore, A.P.S. (2019). Adaptive immune responses to primary and secondary dengue virus infections. Nature Reviews Immunology. doi: 10.1038/s41577-019-0123-x




Mantri CK, St. John AL (2018) Immune synapses between mast cells and γδ T cells limit viral infection. Journal of Clinical Investigation. doi:10.1172/JCI122530




Arifuzzaman A,  Ang WXG,  Choi HW, Nilles ML, St. John AL, and Abraham SN. (2018) Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes. JCI Insight. doi:10.1172/jci.insight.122188


Rathore APS, St. John AL. (2018) Immune responses to dengue virus in the skin. Open Biology. 8: 180087. doi:10.1098/rsob.180087 

St John, A.L., Ang, W.X.G., Rathore, A.P.S., Abraham, S.N. Reprograming immunity to food allergens. (2018) The Journal of Allergy and Clinical Immunology. doi:10.1016/j.jaci.2018.01.020.





Saron, W.A.A., Rathore, A.P.S., Ting, L., Ooi, E.E., Low, J.,  Abraham, S.N., and St. John, A.L. Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells. Science Advances. 4 (2018). doi: 10.1126/sciadv.aar4297


Malavige, G.N., Wijewickrama, A., Fernando, S., Jeewandara, C., Ginneliya, A., Samarasekara, S., Madushanka, P., Punchihewa, C., Paranavitane, S., Idampitiya, D., Wanigatunga, C., Dissanayake, H. Prathapan, S., Gomes, L., Aman, S.A.B., St. John, A.L, & Ogg, G.S. (2018) A preliminary study on efficacy of rupatadine for the treatment of acute dengue infection. Scientific Reports. doi: 10.1038/s41598-018-22285-x



Tissera, H., Rathore, A.P.S., Leong, W.Y., Pike, B.L., Warkentien, T.E., Farouk, F.S., Syenina, A., Ooi, E.E., Gubler, D.J., Wilder-Smith, A., St. John, A.L. (2017) Chymase is a Predictive Biomarker of Dengue Hemorrhagic Fever in Pediatric and Adult Patients. Journal of Infectious Diseases. doi: 10.1093/infdis/jix447 




Morrison, J., Rathore, A.P.S., Mantri, C.K., Aman, S.A.B, Nishida, A. and St. John, A.L. (2017) Transcriptional Profiling Confirms the Therapeutic Effects of Mast Cell Stabilization in a Dengue Disease Model. Journal of Virology. doi:10.1128/JVI.00617-17




Chan, KR, Wang, X, Saron, WAA, Gan, ES, Tan, HC, Mok, DZL, Zhang, SLX, Lee, Yie Hou, Liang, C, Wijaya, L, Ghosh, S, Cheung, YB, Tannenbaum, SR, Abraham, SN, St. John, AL, Low, JGH, Ooi, EE. (2016) Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity. Nature Microbiology. 1, 16164, doi:10.1038/nmicrobiol.2016.164


Goh KC, Tang CK, Norton DC, Gan ES, Tan HC, Sun B, Syenina A, Yousuf A, Ong XM, Kamaraj US, Cheung YB, Gubler DJ, Davidson A, St John AL, Sessions OM, Ooi EE. (2016) Molecular determinants of plaque size as an indicator of dengue virus attenuation. Scientific Reports. May 17;6:26100. doi: 10.1038/srep26100



Gómez, J.M.M., O, L.C., Lam, J.H., Aman, S.A.B., Libau, E.A., Lee, P.X., St. John, A.L., Alonso, S. (2016). Maternal antibody-mediated disease enhancement in type I interferon-deficient mice leads to lethal disease associated with liver damage. PLoS Neglected Tropical Diseases. Mar 23; 10(3):e0004536. doi: 10.1371/journal.pntd.0004536


Li, J.L., Lim, C.H., Tay, F.W., Goh, C.C., Devi, S., Malleret, B., Lee, B., Bakocevic, N., Chong, S.Z., Evrard, M., Tanizaki, H., Lim, H.Y., Russell, B., Renia, L., Zolezzi, F., Poidinger, M., Angeli, V., St. John, A.L., Harris, J.E., Tey, H.L., Tan, S.M., Kabashima, K., Weninger, W., Larbi, A., Ng, L.G. (2015) Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation Through CXCL2. Journal of Investigative Dermatology. doi: 10.1038/JID.2015.410



Syenina, A., Jagaraj, C.J., Aman, S.A., Sridharan, A. and St John, A.L. (2015) Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors. eLife. Mar 18;4. doi: 10.7554/eLife.05291



St. John, A.L., Ang, W.X.G., Huang, M.N., Kunder, C.A., Chan, E.W., Gunn, M.D., Abraham, S.N. (2014) S1P-dependent trafficking of intracellular Yersinia pestis through lymph nodes establishes bubos and systemic infection. Immunity. Sep 18;41(3):440-50. doi: 10.1016/j.immuni.2014.07.013




Gubler, D. J. & St. John, A. L., “Dengue Viruses” in Reference Module in Biomedical Sciences   (Elsevier, 2014). (book chapter)




St. John, A.L. (2013). Influence of Mast Cells on Dengue Protective Immunity and Immune Pathology. PLoS Pathogens. 9(12): e1003783. doi: 0.1371/journal.ppat.1003783



St. John, A.L., Abraham, S. N., and Gubler, D. J. (2013). Barriers to Pre-Clinical Investigations of Anti-Dengue Immunity and Immune-pathology. Nature Reviews Microbiology. Jun;11(6):420-6. doi: 10.1038/nrmicro3030



St. John, A.L.*, Rathore, A. P. S., Raghavan, B., Ng, M. L., and Abraham, S. N. (2013). Contributions of Mast Cells and Vasoactive Products, Leukotrienes and Chymase, to Dengue Virus-Induced Vascular Leakage. eLife. Apr 30;2:e00481. (Featured article with commentary) doi: 10.7554/eLife.00481



St. John, A.L.*, and Abraham, S. N. (2013). Innate Immunity and its Regulation by Mast Cells. Journal of Immunology. May 1;190(9):4458-63. doi: 10.4049/jimmunol.1203420





Chan, C.Y., St John, A.L., & Abraham, S.N., (2013). Mast cell interleukin-10 drives localized tolerance in chronic bladder infection. Immunity 38 (2), 349-359. doi: 10.1016/j.immuni.2012.10.019





St John, A.L.*, Chan, C.Y., Staats, H.F., Leong, K.W. & Abraham, S.N. (2012). Synthetic Mast Cell Granules as Adjuvants to Promote and Polarize Immunity in Lymph Nodes. Nature Materials 11 (3), 250-257.  (Featured in “News and Views”) doi: 10.1038/nmat3222




Kunder, C.A., St John, A.L.* & Abraham, S.N. (2011). Mast cell modulation of the vascular and lymphatic endothelium. Blood. 118 (20), 5383-5393. doi: 10.1182/blood-2011-07-358432





Chan, C.Y., St John, A.L., & Abraham, S.N. (2011). Plasticity in mast cell responses during bacterial infections. Current Opinion in Microbiology 15 (1), 78-84. doi: 10.1016/j.mib.2011.10.007





St John, A.L.*, Rathore, A., Yap, H., Metcalfe, D., Ng, M.M., Vasudevan, S. and Abraham, S.N. (2011). Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance.  Proceedings of the National Academy of Sciences U S A. 108 (22), 9190-9195 (2011). doi: 10.1073/pnas.1105079108




Abraham, S.N. and St John, A.L. (2010). Mast cell-orchestrated immunity to pathogens. Nature Reviews Immunology 10(6):440-452. doi:10.1038/nri2782 





St John, A.L., and Abraham, S.N. (2009). Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. Nature Medicine 15, 1259-1265. doi: 10.1038/nm.2036





Kunder*, C.A., St John*, A.L., Li, G., Leong, K.W., Berwin, B., Staats, H.F., and Abraham, S.N. (2009). Mast cell-derived particles deliver peripheral signals to remote lymph nodes. Journal of Experimental Medicine 206, 2455-2467. doi: 10.1084/jem.20090805




Shelburne, C.P., Nakano, H., St John, A.L., Chan, C., McLachlan, J.B., Gunn, M.D., Staats, H.F., and Abraham, S.N. (2009). Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues. Cell Host & Microbe 6, 331-342. 




Dzhagalov, I., St John, A., and He, Y.W. (2007). The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood 109, 1620-1626. 

Laboratory of Immunity and Immune Pathology | Duke-NUS Medical School